Effective gene silencing activity of prodrug-type 2′-O-methyldithiomethyl siRNA compared with non-prodrug-type 2′-O-methyl siRNA-Reference-Cited by-同舟云学术

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Effective gene silencing activity of prodrug-type 2′-O-methyldithiomethyl siRNA compared with non-prodrug-type 2′-O-methyl siRNA

Published:2018-07 Issue:12 Volume:28 Page:2171-2174
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Hayashi Junsuke,Nishigaki Misa,Ochi Yosuke,Wada Shun-ichi,Wada Fumito,Nakagawa Osamu,Obika Satoshi,Harada-Shiba Mariko,Urata Hidehito

Funder

Ministry of Education

National Institute of Biomedical Innovation

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference31 articles.

1. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

2. Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2'-O-methyl RNA, phosphorothioates and small interfering RNA

3. The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides

4. Characterization of fully 2'-modified oligoribonucleotide hetero- and homoduplex hybridization and nuclease sensitivity

5. Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA

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2. RNA Control via Redox‐Responsive Acylation;Angewandte Chemie;2024-04-03

3. Rational design of prodrug-type apoB-targeted siRNA for nuclease resistance improvement without compromising gene silencing potency;Bioorganic & Medicinal Chemistry;2024-04

4. Triggering RNA Interference by Photoreduction under Red Light Irradiation;Molecules;2023-05-20

5. 2′-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity;Nucleic Acid Therapeutics;2022-06-01

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