2′-<i>O</i>-(<i>N</i>-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity-Reference-Cited by-同舟云学术

2′-O-(N-(Aminoethyl)carbamoyl)methyl Modification Allows for Lower Phosphorothioate Content in Splice-Switching Oligonucleotides with Retained Activity

Published:2022-06-01 Issue:3 Volume:32 Page:221-233
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Honcharenko Dmytro¹,Rocha Cristina S.J.²^ORCID,Lundin Karin E.²,Maity Jyotirmoy¹,Milton Stefan¹,Tedebark Ulf¹,Murtola Merita¹,Honcharenko Malgorzata¹,Slaitas Andis³,Smith C.I. Edvard²,Zain Rula²⁴,Strömberg Roger¹^ORCID

Affiliation:

1. Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge, Sweden.

2. Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Karolinska University Hospital, Huddinge, Sweden.

3. Syntagon Baltic, Babites novads, Latvia.

4. Department of Clinical Genetics, Center for Rare Diseases, Karolinska University Hospital, Stockholm, Sweden.

Publisher

Mary Ann Liebert Inc

Subject

Drug Discovery,Genetics,Molecular Biology,Molecular Medicine,Biochemistry

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2021.0086

Reference72 articles.

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