Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA
Author:
Affiliation:
1. Departments of Medicinal Chemistry, Antisense Lead Identification, and Research Chemistry, Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, California 92008
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm049167j
Reference35 articles.
1. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
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4. Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi
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