Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA-Reference-Cited by-同舟云学术

Fully 2‘-Modified Oligonucleotide Duplexes with Improved in Vitro Potency and Stability Compared to Unmodified Small Interfering RNA

Published:2005-01-20 Issue:4 Volume:48 Page:901-904
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Allerson Charles R.¹,Sioufi Namir¹,Jarres Russell¹,Prakash Thazha P.¹,Naik Nishant¹,Berdeja Andres¹,Wanders Lisa¹,Griffey Richard H.¹,Swayze Eric E.¹,Bhat Balkrishen¹

Affiliation:

1. Departments of Medicinal Chemistry, Antisense Lead Identification, and Research Chemistry, Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, California 92008

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049167j

Reference35 articles.

1. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems

3. An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

4. Single-Stranded Antisense siRNAs Guide Target RNA Cleavage in RNAi

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