mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs <i>In Vivo</i>-Reference-Cited by-同舟云学术

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mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo

Published:2024-08-01 Issue:4 Volume:34 Page:164-172
ISSN:2159-3337
Container-title:Nucleic Acid Therapeutics
language:en
Short-container-title:Nucleic Acid Therapeutics

Author:

Allen Sarah¹,O’Reilly Daniel¹,Miller Rachael¹²,Sapp Ellen³,Summers Ashley¹,Paquette Joseph¹²,Echeverria Moreno Dimas¹,Bramato Brianna¹,McHugh Nicholas¹,Yamada Ken¹,Aronin Neil¹²,DiFiglia Marian³,Khvorova Anastasia¹

Affiliation:

1. RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.

2. Department of Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.

3. Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA.

Publisher

Mary Ann Liebert Inc

Link

https://www.liebertpub.com/doi/pdf/10.1089/nat.2024.0027

Reference32 articles.

1. Huntington's disease: a clinical review

2. A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

3. Huntington's disease: from molecular pathogenesis to clinical treatment

4. CAG Repeat Not Polyglutamine Length Determines Timing of Huntington’s Disease Onset

5. Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease

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