Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme-Reference-Cited by-同舟云学术

Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme

Published:2016-09 Issue:17 Volume:26 Page:4345-4349
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Bensasson René V.,Dinkova-Kostova Albena T.,Zheng Suqing,Saito Akira,Li Wei,Zoete Vincent,Honda Tadashi

Funder

Stony Brook Foundation

Reata Pharmaceuticals Inc.

Muséum National d’Histoire Naturelle

Solidar-Immun Foundation

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

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3. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

4. The Antioxidant Defense System Keap1-Nrf2 Comprises a Multiple Sensing Mechanism for Responding to a Wide Range of Chemical Compounds

5. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism

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2. C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape;Scientific Reports;2018-05-23

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