Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants
Author:
Funder
Cancer Research UK
BBSRC
Publisher
Elsevier BV
Subject
Molecular Biology,Biochemistry,Biophysics
Reference108 articles.
1. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements;Itoh;Biochem. Biophys. Res. Commun.,1997
2. The Nrf2 regulatory network provides an interface between redox and intermediary metabolism;Hayes;Trends Biochem. Sci.,2014
3. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain;Itoh;Genes Dev.,1999
4. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase;Cullinan;Mol. Cell Biol,2004
5. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2;Kobayashi;Mol. Cell Biol.,2004
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