C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape-Reference-Cited by-同舟云学术

C151 in KEAP1 is the main cysteine sensor for the cyanoenone class of NRF2 activators, irrespective of molecular size or shape

Published:2018-05-23 Issue:1 Volume:8 Page:
ISSN:2045-2322
Container-title:Scientific Reports
language:en
Short-container-title:Sci Rep

Author:

Dayalan Naidu Sharadha,Muramatsu Aki,Saito Ryota,Asami Soichiro,Honda Tadashi,Hosoya Tomonori,Itoh Ken,Yamamoto Masayuki,Suzuki Takafumi,Dinkova-Kostova Albena T.

Publisher

Springer Science and Business Media LLC

Subject

Multidisciplinary

Link

http://www.nature.com/articles/s41598-018-26269-9.pdf

Reference62 articles.

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3. Cullinan, S. B., Gordan, J. D., Jin, J., Harper, J. W. & Diehl, J. A. The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase. Mol Cell Biol 24, 8477–8486, https://doi.org/10.1128/MCB.24.19.8477-8486.2004 (2004).

4. Zhang, D. D., Lo, S. C., Cross, J. V., Templeton, D. J. & Hannink, M. Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex. Mol Cell Biol 24, 10941–10953, https://doi.org/10.1128/MCB.24.24.10941-10953.2004 (2004).

5. Kobayashi, A. et al. Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. Mol Cell Biol 24, 7130–7139, https://doi.org/10.1128/MCB.24.16.7130-7139.2004 (2004).

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