Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile-Reference-Cited by-同舟云学术

Discovery of potent aryl-substituted 3-[(3-methylpyridine-2-carbonyl) amino]-2,4-dimethyl-benzoic acid EP4 antagonists with improved pharmacokinetic profile

Published:2016-02 Issue:3 Volume:26 Page:931-935
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Blanco Maria-Jesus,Vetman Tatiana,Chandrasekhar Srinivasan,Fisher Matthew J.,Harvey Anita,Chambers Mark,Lin Chaohua,Mudra Daniel,Oskins Jennifer,Wang Xu-Shan,Yu Xiao-Peng,Warshawsky Alan M.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference18 articles.

1. COX-2 Signaling and Cancer: New Players in Old Arena

2. Inhibition of protein translation as a novel mechanism for prostaglandin E 2 regulation of cell functions

3. The role of prostanoids in urinary bladder physiology

4. Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis

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