Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis-Reference-Cited by-同舟云学术

Discovery of selective urokinase plasminogen activator (uPA) inhibitors as a potential treatment for multiple sclerosis

Published:2018-11 Issue:20 Volume:28 Page:3372-3375
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Islam Imadul^ORCID,Yuan Shendong,West Christopher W.,Adler Marc,Bothe Ulrich,Bryant Judi,Chang Zheng,Chu Kieu,Emayan Kumar,Gualtieri Giovanna,Ho Elena,Light David,Mallari Cornell,Morser John,Phillips Gary,Schaefer Caralee,Sukovich Drew,Whitlow Marc,Chen Deborah,Buckman Brad O.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. Involvement of Tissue Plasminogen Activator in Onset and Effector Phases of Experimental Allergic Encephalomyelitis

2. A Role for the Plasminogen Activator System in Inflammation and Neurodegeneration in the Central Nervous System during Experimental Allergic Encephalomyelitis

3. Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties

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3. Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity;Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics;2021-02

4. Genome-Wide Multiple Sclerosis Association Data and Coagulation;Frontiers in Neurology;2019-02-14