The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4′-azidocytidine (R1479)-Reference-Cited by-同舟云学术

The application of phosphoramidate ProTide technology to the potent anti-HCV compound 4′-azidocytidine (R1479)

Published:2009-08 Issue:15 Volume:19 Page:4250-4254
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

McGuigan Christopher,Kelleher Mary Rose,Perrone Plinio,Mulready Sinead,Luoni Giovanna,Daverio Felice,Rajyaguru Sonal,Pogam Sophie Le,Najera Isabel,Martin Joseph A.,Klumpp Klaus,Smith David B.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference22 articles.

1. Design, synthesis, and antiviral properties of 4′-substituted ribonucleosides as inhibitors of hepatitis C virus replication: The discovery of R1479

2. The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture

3. Current Prodrug Strategies for the Delivery of Nucleotides into Cells

4. Aryl Phosphoramidate Derivatives of d4T Have Improved Anti-HIV Efficacy in Tissue Culture and May Act by the Generation of a Novel Intracellular Metabolite

5. Aryloxy Phosphoramidate Triesters as Pro-Tides

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