Cytotoxicity of phosphoramidate, bis-amidate and cycloSal prodrug metabolites against tumour and normal cells-Reference-Cited by-同舟云学术

Cytotoxicity of phosphoramidate, bis-amidate and cycloSal prodrug metabolites against tumour and normal cells

Published:2024 Issue:6 Volume:15 Page:1973-1981
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Farrell Rebecca E.¹^ORCID,Steele Harrison¹^ORCID,Middleton Ryan J.²^ORCID,Skropeta Danielle¹^ORCID,Liu Guo-Jun²³^ORCID

Affiliation:

1. School of Chemistry & Molecular Bioscience and Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia

2. Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW 2234, Australia

3. Discipline of Medical Imaging Sciences, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia

Abstract

This study reveals varied toxicity of phosph(on)ate prodrug metabolites using sensitive viability assays including a novel CyQUANT assay method.

Funder

Australian Institute of Nuclear Science and Engineering

Department of Education, Australian Government

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D4MD00115J

Reference34 articles.

1. Synthesis of Nucleoside Phosphate and Phosphonate Prodrugs

2. Phosphonates and Phosphonate Prodrugs in Medicinal Chemistry: Past Successes and Future Prospects

3. Prodrugs of pyrophosphates and bisphosphonates: disguising phosphorus oxyanions

4. The ProTide Prodrug Technology: Where Next?

5. A. J.Wiemer and D. F.Wiemer , Prodrugs of Phosphonates and Phosphates: Crossing the Membrane Barrier , Springer International Publishing , 2014 , pp. 115–160