Cytotoxicity of phosphoramidate, bis-amidate and cycloSal prodrug metabolites against tumour and normal cells

Author:

Farrell Rebecca E.1ORCID,Steele Harrison1ORCID,Middleton Ryan J.2ORCID,Skropeta Danielle1ORCID,Liu Guo-Jun23ORCID

Affiliation:

1. School of Chemistry & Molecular Bioscience and Molecular Horizons, Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, NSW 2522, Australia

2. Australian Nuclear Science and Technology Organisation, Lucas Heights, NSW 2234, Australia

3. Discipline of Medical Imaging Sciences, Brain and Mind Centre, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia

Abstract

This study reveals varied toxicity of phosph(on)ate prodrug metabolites using sensitive viability assays including a novel CyQUANT assay method.

Funder

Australian Institute of Nuclear Science and Engineering

Department of Education, Australian Government

Publisher

Royal Society of Chemistry (RSC)

Reference34 articles.

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