Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression-Reference-Cited by-同舟云学术

Design, optimization, and in vivo evaluation of a series of pyridine derivatives with dual NK1 antagonism and SERT inhibition for the treatment of depression

Published:2013-01 Issue:2 Volume:23 Page:407-411
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Gillman Kevin W.,Parker Michael F.,Silva Mark,Degnan Andrew P.,Tora George O.,Lodge Nicholas J.,Li Yu-Wen,Lelas Snjezana,Taber Matthew,Krause Rudolf G.,Bertekap Robert L.,Newton Amy E.,Pieschl Rick L.,Lengyel Kelly D.,Johnson Kim A.,Taylor Sarah J.,Bronson Joanne J.,Macor John E.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference24 articles.

1. Novel Drugs and Therapeutic Targets for Severe Mood Disorders

2. Do Substance P and the NK1 Receptor have a Role in Depression and Anxiety?

3. Discovery of orally bioavailable NK1 receptor antagonists

4. 4,4-Disubstituted Piperidine High-Affinity NK1 Antagonists: Structure−Activity Relationships and in Vivo Activity

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The Effect of Dezocine on the Median Effective Dose of Sufentanil-Induced Respiratory Depression in Patients Undergoing Spinal Anesthesia Combined with Low-Dose Dexmedetomidine;Drug Design, Development and Therapy;2023-12

2. Effects of Dezocine on the Reduction of Emergence Delirium after Laparoscopic Surgery: A Retrospective Propensity Score-Matched Cohort Study;Journal of Personalized Medicine;2023-03-28

3. hERG Blockade Prediction by Combining Site Identification by Ligand Competitive Saturation and Physicochemical Properties;Chemistry;2022-06-21

4. Recent advances in the catalytic cyclopropanation of unsaturated compounds with diazomethane;Russian Chemical Reviews;2021-03-01

5. Molybdenum-Promoted Synthesis of Isoquinuclidines with Bridgehead CF3 Groups;Journal of the American Chemical Society;2019-11-04