4,4-Disubstituted Piperidine High-Affinity NK1 Antagonists: Structure−Activity Relationships and in Vivo Activity-Reference-Cited by-同舟云学术

4,4-Disubstituted Piperidine High-Affinity NK1 Antagonists: Structure−Activity Relationships and in Vivo Activity

Published:1998-10-09 Issue:23 Volume:41 Page:4623-4635
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Stevenson Graeme I.¹,Huscroft Ian¹,MacLeod Angus M.¹,Swain Christopher J.¹,Cascieri Margaret A.¹,Chicchi Gary G.¹,Graham Michael I.¹,Harrison Timothy¹,Kelleher Fintan J.¹,Kurtz Marc¹,Ladduwahetty Tamara¹,Merchant Kevin J.¹,Metzger Joseph M.¹,MacIntyre D. E.¹,Sadowski Sharon¹,Sohal Balbinder¹,Owens Andrew P.¹

Affiliation:

1. Department of Medicinal Chemistry, Neuroscience Research Centre, Merck, Sharp and Dohme Research Laboratories, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K., and Departments of Pharmacology, Molecular Pharmacology, and Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980376b

Reference38 articles.

1. A Potent Nonpeptide Antagonist of the Substance P (NK 1 ) Receptor

2. Discovery of a potent substance P antagonist: recognition of the key molecular determinant

3. CP-99,994, a nonpeptide antagonist of the tachykinin NK1 receptor

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