Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors-Reference-Cited by-同舟云学术

Synthesis and biological evaluation of ((4-keto)-phenoxy)methyl biphenyl-4-sulfonamides: A class of potent aggrecanase-1 inhibitors

Published:2009-05 Issue:9 Volume:19 Page:2487-2491
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Hopper Darrin W.,Vera Matthew D.,How David,Sabatini Joshua,Xiang Jason S.,Ipek Manus,Thomason Jennifer,Hu Yonghan,Feyfant Eric,Wang Qin,Georgiadis Katy E.,Reifenberg Erica,Sheldon Richard T.,Keohan Cristin C.,Majumdar Manas K.,Morris Elisabeth A.,Skotnicki Jerauld,Sum Phaik-Eng

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference10 articles.

1. Aggrecanase: The Family and Its Inhibitors

2. Matrix metalloproteinase and aggrecanase generated aggrecan fragments: implications for the diagnostics and therapeutics of destructive joint diseases

3. Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins

4. Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice

5. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis

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