Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins-Reference-Cited by-同舟云学术

Purification and Cloning of Aggrecanase-1: A Member of the ADAMTS Family of Proteins

Published:1999-06-04 Issue:5420 Volume:284 Page:1664-1666
ISSN:0036-8075
Container-title:Science
language:en
Short-container-title:Science

Author:

Tortorella M. D.¹,Burn T. C.²,Pratta M. A.¹,Abbaszade I.²,Hollis J. M.²,Liu R.¹,Rosenfeld S. A.²,Copeland R. A.³,Decicco C. P.⁴,Wynn R.²,Rockwell A.⁴,Yang F.³,Duke J. L.²,Solomon K.¹,George H.²,Bruckner R.¹,Nagase H.⁵,Itoh Y.⁵,Ellis D. M.²,Ross H.²,Wiswall B. H.²,Murphy K.²,Hillman M. C.²,Hollis G. F.²,Newton R. C.¹,Magolda R. L.¹,Trzaskos J. M.¹,Arner E. C.¹

Affiliation:

1. Department of Inflammatory Diseases Research,

2. Department of Applied Biotechnology,

3. Department of Enzymology,

4. Department of Chemical and Physical Sciences, DuPont Pharmaceuticals Company, Wilmington, DE 19880–0400, USA.

5. Department of Biochemistry and Molecular Biology, University of Kansas School of Medicine, Kansas City, KS 66160, USA.

Abstract

We purified, cloned, and expressed aggrecanase, a protease that is thought to be responsible for the degradation of cartilage aggrecan in arthritic diseases. Aggrecanase-1 [a disintegrin and metalloproteinase with thrombospondin motifs–4 (ADAMTS-4)] is a member of the ADAMTS protein family that cleaves aggrecan at the glutamic acid-373–alanine-374 bond. The identification of this protease provides a specific target for the development of therapeutics to prevent cartilage degradation in arthritis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

Multidisciplinary

Reference40 articles.

1. Fosang A. J., Neame T. J., Hardingham T. E., Murphy G., Hamilton J. A., J. Biol. Chem. 266, 15579 (1991);

2. Flannery C. R., Lark M. W., Sandy J. D., ibid. 267, 1008 (1992) ;

3. Fosang A. J., et al., Biochem. J. 295, 273 (1993);

4. Fosang A. J., Last K., Knauper V., Murphy G., Neame P. J., FEBS Lett. 380, 17 (1996).

5. Sandy J. D., Neame P. J., Boynton P. L., Flannery C. R., J. Biol. Chem. 266, 8683 (1991);

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