Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X7 receptor-Reference-Cited by-同舟云学术

Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X7 receptor

Published:2011-09 Issue:18 Volume:21 Page:5475-5479
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Subramanyam Chakrapani,Duplantier Allen J.,Dombroski Mark A.,Chang Shang-Poa,Gabel Christopher A.,Whitney-Pickett Carrie,Perregaux David G.,Labasi Jeff M.,Yoon Kwansik,Shepard Richard M.,Fisher Michael

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference19 articles.

1. The P2X7receptor as a therapeutic target

2. Altered Cytokine Production in Mice Lacking P2X7Receptors

3. Antagonists of the P2X7Receptor. From Lead Identification to Drug Development

4. Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535

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