Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535-Reference-Cited by-同舟云学术

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535

Published:2011-06 Issue:12 Volume:21 Page:3708-3711
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Duplantier Allen J.,Dombroski Mark A.,Subramanyam Chakrapani,Beaulieu Aimee M.,Chang Shang-Poa,Gabel Christopher A.,Jordan Crystal,Kalgutkar Amit S.,Kraus Kenneth G.,Labasi Jeff M.,Mussari Christopher,Perregaux David G.,Shepard Rick,Taylor Timothy J.,Trevena Kristen A.,Whitney-Pickett Carrie,Yoon Kwansik

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference15 articles.

1. P2X and P2Y receptors as possible targets of therapeutic manipulations in CNS illnesses

2. Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor−/− mice

3. Altered Cytokine Production in Mice Lacking P2X7Receptors

4. Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

5. P2X7 Mediates Superoxide Production in Primary Microglia and Is Up-regulated in a Transgenic Mouse Model of Alzheimer's Disease

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