4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate-Reference-Cited by-同舟云学术

4-Aryl-3-arylsulfonyl-quinolines as negative allosteric modulators of metabotropic GluR5 receptors: From HTS hit to development candidate

Published:2016-02 Issue:4 Volume:26 Page:1249-1252
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Galambos János,Domány György,Nógrádi Katalin,Wágner Gábor,Keserű György M.,Bobok Amrita,Kolok Sándor,Mikó-Bakk Mónika L.,Vastag Mónika,Sághy Katalin,Kóti János,Szakács Zoltán,Béni Zoltán,Gál Krisztina,Szombathelyi Zsolt,Greiner István

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference25 articles.

1. Novel allosteric antagonists shed light on mglu5 receptors and CNS disorders

2. mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia

3. Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist

4. Anticonvulsant activity of two metabotropic glutamate Group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893)

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