Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5-Reference-Cited by-同舟云学术

Structure-Based Discovery of Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 5

Published:2022-09-23 Issue:10 Volume:17 Page:2744-2752
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Kampen Stefanie¹,Rodríguez David²³^ORCID,Jørgensen Morten³,Kruszyk-Kujawa Monika³,Huang Xinyan⁴,Collins Michael⁴,Boyle Noel⁴,Maurel Damien⁵,Rudling Axel²,Lebon Guillaume⁵,Carlsson Jens¹^ORCID

Affiliation:

1. Science for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, SE-751 24 Uppsala, Sweden

2. Science for Life Laboratory, Department of Biochemistry and Biophysics, Stockholm University, SE-171 21 Solna, Sweden

3. H. Lundbeck A/S, Ottiliavej 9, DK-2500 Valby, Denmark

4. Lundbeck Research USA, 215 College Road, Paramus, New Jersey 07652 - 1431, United States

5. IGF, Université de Montpellier, CNRS, INSERM, 34094 Montpellier, France

Funder

Vetenskapsr?det

Innovationsfonden

H. Lundbeck A/S

H2020 European Research Council

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acschembio.2c00234

Reference61 articles.

1. “Molecular Switches” on mGluR Allosteric Ligands That Modulate Modes of Pharmacology

2. Neuropharmacological Insight from Allosteric Modulation of mGlu Receptors

3. Allosteric binding sites on cell-surface receptors: novel targets for drug discovery

4. Impact of GPCR Structures on Drug Discovery

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