Affiliation:
1. College of Chemistry and Bioengineering, Hunan University of Science and Engineering, Yongzhou 425100, China
Abstract
A mild, efficient and practical protocol for the preparation of 2-sulfonylquinolines through CS2/Et2NH-induced deoxygenative C2-H sulfonylation of quinoline N-oxides with readily available RSO2Cl was developed. The reaction proceeded well under transition-metal-free conditions and exhibited a wide substrate scope and functional group tolerance. The preliminary studies suggested that the nucleophilic sulfonyl sources were generated in situ via the reaction of CS2, Et2NH and sulfonyl chlorides.
Funder
National Natural Science Foundation of China
Science and Technology Innovation Program of Hunan Province
construct program of applied characteristic discipline in Hunan Province