Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor-Reference-Cited by-同舟云学术

Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor

Published:2010-10 Issue:19 Volume:20 Page:5925-5932
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Morriello Gregori J.,Chicchi Gary,Johnson Tricia,Mills Sander G.,DeMartino Julie,Kurtz Marc,Tsao K.L.C.,Zheng Song,Tong Xinchun,Carlson Emma,Townson Karen,Wheeldon Alan,Boyce Susan,Collinson Neil,Rupniak Nadia,DeVita Robert J.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference27 articles.

1. 2(S)-((3,5-Bis(trifluoromethyl)benzyl)oxy)-3(S)-phenyl-4-((3-oxo-1,2,4-triazol- 5-yl)methyl)morpholine (1): A Potent, Orally Active, Morpholine-Based Human Neurokinin-1 Receptor Antagonist

2. Prevention of Cisplatin-Induced Emesis by the Oral Neurokinin-1 Antagonist, MK-869, in Combination With Granisetron and Dexamethasone or With Dexamethasone Alone

3. Addition of the neurokinin 1 receptor antagonist aprepitant to standard antiemetic therapy improves control of chemotherapy-induced nausea and vomiting

4. Tachykinin NK1receptor antagonists for the control of chemotherapy-induced nausea and vomiting

5. Substance P and the Neurokinins: Novel Peptide Neurotransmitters in Psychopharmacology

Cited by 19 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Catalytic Reductive Recyclization of Functionalized Isoxazoline N-Oxides to Pyrrolizidine-3-ones;The Journal of Organic Chemistry;2023-12-14

2. Asymmetric Synthesis of a Pyrrolizidinone‐Based hNK ₁ Antagonist through Reductive Ring Contraction of a Six‐Membered Cyclic Nitronate;European Journal of Organic Chemistry;2022-09-27

3. Three Heterocyclic Rings Fused (5-5-5);Comprehensive Heterocyclic Chemistry IV;2022

4. Recent Advances in the Stereoselective Synthesis of Pyrrolizidin‐3‐ones;Synthetic Approaches to Nonaromatic Nitrogen Heterocycles;2020-10-29

5. Asymmetric Synthesis of Merck’s Potent hNK1 Antagonist and Its Stereoisomers via Tandem Acylation/[3,3]-Rearrangement of 1,2-Oxazine N-Oxides;The Journal of Organic Chemistry;2020-08-11