Asymmetric Synthesis of Merck’s Potent hNK1 Antagonist and Its Stereoisomers via Tandem Acylation/[3,3]-Rearrangement of 1,2-Oxazine N-Oxides-Reference-Cited by-同舟云学术

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Asymmetric Synthesis of Merck’s Potent hNK1 Antagonist and Its Stereoisomers via Tandem Acylation/[3,3]-Rearrangement of 1,2-Oxazine N-Oxides

Published:2020-08-11 Issue:17 Volume:85 Page:11060-11071
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Dorokhov Valentin S.¹,Nelyubina Yulia V.²,Ioffe Sema L.¹,Sukhorukov Alexey Yu.¹³^ORCID

Affiliation:

1. N. D. Zelinsky Institute of Organic Chemistry, Leninsky prospect, 47, Moscow 119991, Russia

2. A. N. Nesmeyanov Institute of Organoelement Compounds, Vavilov str. 28, Moscow 119991, Russia

3. Plekhanov Russian University of Economics, Stremyanny per. 36, Moscow 117997, Russia

Funder

Russian Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.0c01322

Reference41 articles.

1. Tachykinins and Their Receptors: Contributions to Physiological Control and the Mechanisms of Disease

2. Tachykinins and Tachykinin Receptors: Structure and Activity Relationships

3. Tachykinin Receptors Antagonists: From Research to Clinic

4. Prevention of chemotherapy-induced nausea: the role of neurokinin-1 (NK1) receptor antagonists

5. Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

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4. Nitronate-aryne cycloaddition as a concise route to stereochemically complex fused benzisoxazolines and amino alcohols;Organic & Biomolecular Chemistry;2023

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