Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist-Reference-Cited by-同舟云学术

Structural Optimization Affording 2-(R)-(1-(R)-3,5-Bis(trifluoromethyl)phenylethoxy)-3-(S)-(4-fluoro)phenyl-4- (3-oxo-1,2,4-triazol-5-yl)methylmorpholine, a Potent, Orally Active, Long-Acting Morpholine Acetal Human NK-1 Receptor Antagonist

Published:1998-10-02 Issue:23 Volume:41 Page:4607-4614
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hale Jeffrey J.¹,Mills Sander G.¹,MacCoss Malcolm¹,Finke Paul E.¹,Cascieri Margaret A.¹,Sadowski Sharon¹,Ber Elzbieta¹,Chicchi Gary G.¹,Kurtz Marc¹,Metzger Joseph¹,Eiermann George¹,Tsou Nancy N.¹,Tattersall F. David¹,Rupniak Nadia M. J.¹,Williams Angela R.¹,Rycroft Wayne¹,Hargreaves Richard¹,MacIntyre D. Euan¹

Affiliation:

1. Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, and Neuroscience Research Centre, Merck, Sharp & Dohme, Terlings Park, Eastwick Road, Harlow, Essex CM20 2QR, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980299k

Reference40 articles.

1. A non-peptide NK1-receptor antagonist, RP 67580, inhibits neurogenic inflammation postsynaptically

2. Substance P antagonists and analgesia: A review of the hypothesis

3. Preliminary findings on the role of neuropeptide suppression by topical agents in the management of rheumatoid arthritis

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