Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine (23)-Reference-Cited by-同舟云学术

Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2-(2,5-difluorophenyl)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]tetrahydro-2H-pyran-3-amine (23)

Published:2013-10 Issue:19 Volume:23 Page:5361-5366
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Biftu Tesfaye,Qian Xiaoxia,Chen Ping,Feng Dennis,Scapin Giovanna,Gao Ying-Duo,Cox Jason,Sinha Roy Ranabir,Eiermann George,He Huabing,Lyons Kathy,Salituro Gino,Patel Sangita,Petrov Alexander,Xu Feng,Xu Shiyao Sherrie,Zhang Bei,Caldwell Charles,Wu Joseph K.,Lyons Kathy,Weber Ann E.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference14 articles.

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2. Medicinal chemistry approaches to the inhibition of dipeptidyl peptidase-4 for the treatment of type 2 diabetes

3. The incretin system and its role in type 2 diabetes mellitus

4. Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin

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