Heterocyclizations of β-alkoxy, β-diaminoalkyl, and related
β-functionalized enones (enals) with NCN-binucleophiles
-
Published:2022-06-30
Issue:1
Volume:17
Page:56-71
-
ISSN:1814-9766
-
Container-title:Ukr. Bioorg. Acta 2022, Vol. 17, N1
-
language:en
-
Short-container-title:Ukr. Bioorg. Acta
Author:
Vashchenko Bohdan1ORCID, Grygorenko Oleksandr1ORCID, Stepaniuk Oleksandr1ORCID
Affiliation:
1. Taras Shevchenko National University of Kyїv
Abstract
This review provides a detailed survey of the present literature data on β-alkoxyvinyl- and β-enaminocarbonyl compounds as CCC bis-electrophiles in reactions with the common NCN-binucleophiles. The focus is put mostly on the reactions leading to low-molecular-weight and functionalized pyrimidines as the products that are of special interest as building blocks for drug discovery
Funder
Enamine Ministry of Education and Science of Ukraine
Publisher
National Academy of Sciences of Ukraine (Co. LTD Ukrinformnauka) (Publications)
Reference224 articles.
1. Gilchrist, T. L. Heterocyclic chemistry, 3rd Ed.; Addison Wesley: Essex, England, 1997. 2. Joule, J. A.; Mills, K. Heterocyclic chemistry, 5th Ed.; Wiley-Blackwell, 2010. 3. Panneer Selvam, T.; Richa James, C.; Vijaysarathy Dniandev, P.; Karyn Valzita, S. A mini review of pyrimidine and fused pyrimidine marketed drugs. Res. Pharm. 2012, 2, 1-9. 4. De La Torre, B. G.; Albericio, F. The pharmaceutical industry in 2017. An analysis of FDA drug approvals from the perspective of molecules. Molecules 2018, 23, 533. 5. Shirude, P. S.; Shandil, R.; Sadler, C.; Naik, M.; Hosagrahara, V.; Hameed, S.; Shinde, V.; Bathula, C.; Humnabadkar, V.; Kumar, N.; Reddy, J.; Panduga, V.; Sharma, S.; Ambady, A.; Hegde, N.; Whiteaker, J.; McLaughlin, R. E.; Gardner, H.; Madhavapeddi, P.; Ramachandran, V.; Kaur, P.; Narayan, A.; Guptha, S.; Awasthy, D.; Narayan, C.; Mahadevaswamy, J.; Vishwas, K. G.; Ahuja, V.; Srivastava, A.; Prabhakar, K.; Bharath, S.; Kale, R.; Ramaiah, M.; Choudhury, N. R.; Sambandamurthy, V. K.; Solapure, S.; Iyer, P. S.; Narayanan, S.; Chatterji, M. Azaindoles: noncovalent DprE1 inhibitors from scaffold morphing efforts, kill mycobacterium tuberculosis and are efficacious in vivo. J. Med. Chem. 2013, 56, 9701-9708.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
|
|