Discovery of [ 11 C ] MK - 8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors-Reference-Cited by-同舟云学术

Discovery of [ 11 C ] MK - 8193 as a PET tracer to measure target engagement of phosphodiesterase 10A (PDE10A) inhibitors

Published:2015-11 Issue:21 Volume:25 Page:4893-4898
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Cox Christopher D.,Hostetler Eric D.,Flores Broc A.,Evelhoch Jeffrey L.,Fan Hong,Gantert Liza,Holahan Marie,Eng Waisi,Joshi Aniket,McGaughey Georgia,Meng Xiangjun,Purcell Mona,Raheem Izzat T.,Riffel Kerry,Yan Youwei,Renger John J.,Smith Sean M.,Coleman Paul J.

Funder

Merck

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference32 articles.

1. Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition

2. Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia

3. Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia

4. PDE10A Inhibitors: Novel Therapeutic Drugs for Schizophrenia

Cited by 18 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Effects of PDE10A inhibitor MK-8189 in people with an acute episode of schizophrenia: A randomized proof-of-concept clinical trial;Schizophrenia Research;2024-08

2. Fragment-based drug discovery for disorders of the central nervous system: designing better drugs piece by piece;Frontiers in Chemistry;2024-04-18

3. Discovery of MK-8189, a Highly Potent and Selective PDE10A Inhibitor for the Treatment of Schizophrenia;Journal of Medicinal Chemistry;2023-01-10

4. Discovery of a highly specific 18F-labeled PET ligand for phosphodiesterase 10A enabled by novel spirocyclic iodonium ylide radiofluorination;Acta Pharmaceutica Sinica B;2021-11

5. Advances in Cyclic Nucleotide Phosphodiesterase-Targeted PET Imaging and Drug Discovery;Journal of Medicinal Chemistry;2021-05-27