Effect of 2′- O -[2-[2-( N , N -dimethylamino)ethoxy]ethyl] modification on activity of gapmer antisense oligonucleotides containing 2′,4′-constrained 2′- O -ethyl nucleic acid-Reference-Cited by-同舟云学术

Effect of 2′- O -[2-[2-( N , N -dimethylamino)ethoxy]ethyl] modification on activity of gapmer antisense oligonucleotides containing 2′,4′-constrained 2′- O -ethyl nucleic acid

Published:2015-04 Issue:8 Volume:25 Page:1688-1691
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Pandey Sanjay K.,Nowak Anna,Perkins Jake,Ferng Annie,Prakash Thazha P.

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference11 articles.

1. Basic Principles of Antisense Therapeutics;Crooke,1998

2. RNA Targeting Therapeutics: Molecular Mechanisms of Antisense Oligonucleotides as a Therapeutic Platform

3. TricycloDNA-modified oligo-2′-deoxyribonucleotides reduce scavenger receptor B1 mRNA in hepatic and extra-hepatic tissues—a comparative study of oligonucleotide length, design and chemistry

4. Synthesis and Antisense Properties of 2′-O-(2S-Methoxypropyl)-RNA-Modified Gapmer Antisense Oligonucleotides

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