Synthesis of 2′-O-[3-(N-methylsulfamoyl)propan-1-yl]ribothymidine as a potentially applicable 2′-modified nucleoside for antisense oligonucleotides-Reference-Cited by-同舟云学术

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Synthesis of 2′-O-[3-(N-methylsulfamoyl)propan-1-yl]ribothymidine as a potentially applicable 2′-modified nucleoside for antisense oligonucleotides

Published:2022-11 Issue: Volume:73 Page:117002
ISSN:0968-0896
Container-title:Bioorganic & Medicinal Chemistry
language:en
Short-container-title:Bioorganic & Medicinal Chemistry

Author:

Tomori Takahito,Uekusa Koya,Koyama Aya,Kanagawa Takayuki,Masaki Yoshiaki,Seio Kohji

Funder

Japan Society for the Promotion of Science

Ministry of Education, Culture, Sports, Science and Technology

Tokyo Institute of Technology

Precursory Research for Embryonic Science and Technology

Japan Agency for Medical Research and Development

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference30 articles.

1. The chemical evolution of oligonucleotide therapies of clinical utility;Khvorova;Nat Biotechnol,2017

2. Chemically modified siRNA: tools and applications;Watts;Drug Discov Today,2008

3. Chemical modification: the key to clinical application of RNA interference?;Corey;J Clin Invest,2007

4. RNAi therapeutics: a potential new class of pharmaceutical drugs;Bumcrot;Nat Chem Biol,2006

5. 2'-Carbohydrate modifications in antisense oligonucleotide therapy: importance of conformation, configuration and conjugation;Manoharan;Biochim Biophs Acta,1999

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1. Synthesis and Conformational Analyses of Cyclonucleoside Having 13-Membered Ring Bridging Nucleobase and 5′-Position via a Linker Containing Sulfonamide;Organic Letters;2023-10-19

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