Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4-Reference-Cited by-同舟云学术

Discovery and hit-to-lead optimization of 2,6-diaminopyrimidine inhibitors of interleukin-1 receptor-associated kinase 4

Published:2015-05 Issue:9 Volume:25 Page:1836-1841
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

McElroy William T.,Michael Seganish W.,Jason Herr R.,Harding James,Yang Jinhai,Yet Larry,Komanduri Venukrishnan,Prakash Koraboina Chandra,Lavey Brian,Tulshian Deen,Greenlee William J.,Sondey Christopher,Fischmann Thierry O.,Niu Xiaoda

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference20 articles.

1. Epidemiology and Estimated Population Burden of Selected Autoimmune Diseases in the United States

2. Clinically validated approaches to the treatment of autoimmune diseases

3. IRAK-4: A novel member of the IRAK family with the properties of an IRAK-kinase

4. The interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress

5. TLR signaling pathways

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