Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor–associated kinase 4 (IRAK4)
Author:
Funder
HHS National Institutes of Health
Publisher
Elsevier BV
Subject
Cell Biology,Molecular Biology,Biochemistry
Reference44 articles.
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2. The interleukin-1 family: back to the future;Garlanda;Immunity,2013
3. Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling;Lin;Nature,2010
4. An oligomeric signaling platform formed by the Toll-like receptor signal transducers MyD88 and IRAK-4;Motshwene;J. Biol. Chem,2009
5. IRAK4 dimerization and trans-autophosphorylation are induced by myddosome assembly;Ferrao;Mol. Cell,2014
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1. Discovery of LC-MI-3: A Potent and Orally Bioavailable Degrader of Interleukin-1 Receptor-Associated Kinase 4 for the Treatment of Inflammatory Diseases;Journal of Medicinal Chemistry;2024-05-09
2. Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839;Journal of Medicinal Chemistry;2024-01-17
3. Unraveling Extremely Damaging IRAK4 Variants and Their Potential Implications for IRAK4 Inhibitor Efficacy;Journal of Personalized Medicine;2023-11-26
4. Tolerogenic dendritic cells and TLR4/IRAK4/NF-κB signaling pathway in allergic rhinitis;Frontiers in Immunology;2023-10-17
5. The recent advance of Interleukin-1 receptor associated kinase 4 inhibitors for the treatment of inflammation and related diseases;European Journal of Medicinal Chemistry;2023-10
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