Discovery of IRAK4 Inhibitors BAY1834845 (Zabedosertib) and BAY1830839
Author:
Affiliation:
1. Bayer AG, Research & Development, Pharmaceuticals, 13353 Berlin, Germany
Funder
Bayer
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01714
Reference51 articles.
1. The interleukin-1 receptor-associated kinases: Critical regulators of innate immune signalling
2. Innate Immune Recognition
3. Immunological and Inflammatory Functions of the Interleukin-1 Family
4. An Oligomeric Signaling Platform Formed by the Toll-like Receptor Signal Transducers MyD88 and IRAK-4
5. Sequential Autophosphorylation Steps in the Interleukin-1 Receptor-associated Kinase-1 Regulate its Availability as an Adapter in Interleukin-1 Signaling
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