Synthesis and evaluation of novel fused pyrimidine derivatives as GPR119 agonists-Reference-Cited by-同舟云学术

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Synthesis and evaluation of novel fused pyrimidine derivatives as GPR119 agonists

Published:2019-05 Issue: Volume:86 Page:103-111
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Fang Yuanying,Xiong Lijuan,Hu Jianguo,Zhang Shaokun,Xie Saisai,Tu Liangxing,Wan Yang,Jin Yi,Li Xiang,Hu Shaojie,Yang Zunhua

Funder

National Natural Science Foundation of China

Jiangxi Provincial Department of Science and Technology

Hongcheng Haiou Plan of Nanchang City

Health and Family Planning Commission of Jiangxi Province

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference23 articles.

1. Discovery of 5-chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an antidiabetic clinical candidate targeting GPR119;Wacker;J. Med. Chem.,2014

2. Circumventing seizure activity in a series of G protein coupled receptor 119 (GPR119) agonists;Scott;J. Med. Chem.,2014

3. Design, synthesis, and biological evaluation of aryl N-methoxyamide derivatives as GPR119 agonists;Jang;Bioorg. Med. Chem. Lett.,2017

4. GPR119, a novel G protein-coupled receptor target for the treatment of type 2 diabetes and obesity;Overton;Br. J. Pharmacol.,2010

5. Chapter 7 The Emergence of GPR119 Agonists as Anti-Diabetic Agents;Jones;Annu. Rep. Med. Chem.,2009

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis, Characterization, Antimicrobial, and Molecular Docking Studies of Thiazolidin-4-one Derivatives fused with Indole and Pyrimidine Moieties;Russian Journal of Bioorganic Chemistry;2023-11

2. Six-membered ring (with N, O or S) fused pyrimidine-based derivatives and biological properties;Fused Pyrimidine-Based Drug Discovery;2023

3. Synthesis, Characterization, Biological, and Molecular Docking Studies of (Z)-N-Substituted-4-(Pyridin-2-yl)-6-(1H-Pyrrolo[2,3-b]Pyridin-4-yl)Pyrimidin-2-Amine;Russian Journal of Bioorganic Chemistry;2022-07-28

4. Targeting the GPR119/incretin axis: a promising new therapy for metabolic-associated fatty liver disease;Cellular & Molecular Biology Letters;2021-07-07

5. GPR119 agonists for the treatment of type 2 diabetes: an updated patent review (2014-present);Expert Opinion on Therapeutic Patents;2021-05-10

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