Discovery of 5-Chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an Antidiabetic Clinical Candidate Targeting GPR119-Reference-Cited by-同舟云学术

Discovery of 5-Chloro-4-((1-(5-chloropyrimidin-2-yl)piperidin-4-yl)oxy)-1-(2-fluoro-4-(methylsulfonyl)phenyl)pyridin-2(1H)-one (BMS-903452), an Antidiabetic Clinical Candidate Targeting GPR119

Published:2014-09-10 Issue:18 Volume:57 Page:7499-7508
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wacker Dean A.¹,Wang Ying¹,Broekema Matthias¹,Rossi Karen¹,O’Connor Steven¹,Hong Zhenqiu¹,Wu Ginger¹,Malmstrom Sarah E.¹,Hung Chen-Pin¹,LaMarre Linda¹,Chimalakonda Anjaneya¹,Zhang Lisa¹,Xin Li¹,Cai Hong¹,Chu Cuixia¹,Boehm Stephanie¹,Zalaznick Jacob¹,Ponticiello Randolph¹,Sereda Larisa¹,Han Song-Ping¹,Zebo Rachel¹,Zinker Bradley¹,Luk Chiuwa Emily¹,Wong Richard¹,Everlof Gerry¹,Li Yi-Xin¹,Wu Chunyu K.¹,Lee Michelle¹,Griffen Steven¹,Miller Keith J.¹,Krupinski John¹,Robl Jeffrey A.¹

Affiliation:

1. Departments of Discovery Chemistry, Metabolic Diseases, Lead Evaluation, Computer-Assisted Drug Design, Discovery Toxicology, Exploratory Clinical and Translational Research, and Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, P.O. Box 5400, Princeton, New Jersey 08543-5400, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm501175v

Reference21 articles.

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2. Centers for Disease Control and Prevention, National Diabetes Fact Sheet, 2011.http://www.cdc.gov/diabetes/pubs/pdf/ndfs_2011.pdf, 2011

3. Glycemic Control From 1988 to 2000 Among U.S. Adults Diagnosed With Type 2 Diabetes

4. Treating type 2 diabetes: how safe are current therapeutic agents?

5. The incretin system and its role in type 2 diabetes mellitus

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