Circumventing Seizure Activity in a Series of G Protein Coupled Receptor 119 (GPR119) Agonists
Author:
Affiliation:
1. Innovative Medicines Unit, AstraZeneca Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.
2. Pharmaceutical Development, AstraZeneca R&D, S-151 85 Södertälje, Sweden
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm5011012
Reference57 articles.
1. Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives
2. Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents
3. N-Oleoyldopamine Enhances Glucose Homeostasis through the Activation of GPR119
4. A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release
5. A Role for β-Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucose-Dependent Insulin Release
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