Design, synthesis and pharmacological evaluation of 2-arylurea-1,3,5-triazine derivative (XIN-9): A novel potent dual PI3K/mTOR inhibitor for cancer therapy-Reference-Cited by-同舟云学术

Design, synthesis and pharmacological evaluation of 2-arylurea-1,3,5-triazine derivative (XIN-9): A novel potent dual PI3K/mTOR inhibitor for cancer therapy

Published:2022-12 Issue: Volume:129 Page:106157
ISSN:0045-2068
Container-title:Bioorganic Chemistry
language:en
Short-container-title:Bioorganic Chemistry

Author:

Sun Xin,Zhang Binliang,Luo Leixuan,Yang Yang,He Bin,Zhang Qian,Wang Linxiao,Xu Shan,Zheng Pengwu,Zhu Wufu

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Molecular Biology,Biochemistry

Reference36 articles.

1. PI3K and cancer: lessons, challenges and opportunities;Fruman;Nat. Rev. Drug Discovery,2014

2. PI3Kδ and PI3Kγ as targets for autoimmune and inflammatory diseases;Cushing;J. Med. Chem.,2012

3. PI 3-kinase p110β: a new target for antithrombotic therapy;Jackson;Nat. Med.,2005

4. A pharmacological map of the PI3-K family defines a role for p110α in insulin signaling;Knight;Cell,2006

5. The PI3K/AKT pathway in obesity and type 2 diabetes;Huang;Int. J. Biol. Sci.,2018

Cited by 14 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. 1,3,5-Triazine as a promising scaffold in the development of therapeutic agents against breast cancer;European Journal of Medicinal Chemistry;2024-10

2. In silico method and bioactivity evaluation to discover novel antimicrobial agents targeting FtsZ protein: Machine learning, virtual screening and antibacterial mechanism study;Naunyn-Schmiedeberg's Archives of Pharmacology;2024-07-23

3. Recent Advances in Signaling Pathways and Kinase Inhibitors for Leukemia Chemotherapy;Current Medicinal Chemistry;2024-02-16

4. T6496 targeting EGFR mediated by T790M or C797S mutant: machine learning, virtual screening and bioactivity evaluation study;Journal of Biomolecular Structure and Dynamics;2024-01-04

5. Design, synthesis and anticancer evaluation of imamine-1,3,5-triazine derivatives;New Journal of Chemistry;2024