A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling

Author:

Knight Zachary A.,Gonzalez Beatriz,Feldman Morri E.,Zunder Eli R.,Goldenberg David D.,Williams Olusegun,Loewith Robbie,Stokoe David,Balla Andras,Toth Balazs,Balla Tamas,Weiss William A.,Williams Roger L.,Shokat Kevan M.

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference50 articles.

1. Targeting the gatekeeper residue in phosphoinositide 3-kinases;Alaimo;Bioorg. Med. Chem.,2005

2. p110beta is up-regulated during differentiation of 3T3–L1 cells and contributes to the highly insulin-responsive glucose transport activity;Asano;J. Biol. Chem.,2000

3. Barvian, N.C., Kolz, C.N., Para, K.S., Patt, W.C., and Viskick, M. June 2004. Benzoxazin-3-ones and derivatives thereof as inhibitors of PI3K. WO 04/052373.

4. Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110alpha subunit of phosphoinositide 3-kinase;Bi;J. Biol. Chem.,1999

5. Early embryonic lethality in mice deficient in the p110beta catalytic subunit of PI 3-kinase;Bi;Mamm. Genome,2002

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