Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator-Reference-Cited by-同舟云学术

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Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator

Published:2000-04 Issue:4 Volume:7 Page:299-312
ISSN:1074-5521
Container-title:Chemistry & Biology
language:en
Short-container-title:Chemistry & Biology

Author:

Katz Bradley A,Mackman Richard,Luong Christine,Radika Kesavan,Martelli Arnold,Sprengeler Paul A,Wang Jing,Chan Hedy,Wong Lance

Publisher

Elsevier BV

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,Molecular Medicine,General Medicine,Biochemistry

Reference31 articles.

1. On the size of the active site in proteinases. I. Papain;Schechter;Biochem. Biophys. Res. Commun.,1967

2. Structural and functional analyses of benzamidine-based inhibitors in complex with trypsin: implications for the inhibition of factor Xa, tPA, and urokinase;Renatus;J. Med. Chem.,1998

3. Rational design and synthesis of novel, potent bis-phenylamidine carboxylate factor Xa inhibitors;Maduskie;J. Med. Chem.,1998

4. Structure-based design of benzamidine-type inhibitors of factor Xa;Gabriel;J. Med. Chem.,1998

5. X-ray structure of active site-inhibited clotting factor Xa: implications for drug design and substrate recognition;Brandstetter;J. Biol. Chem.,1996

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3. Accurate determination of protein:ligand standard binding free energies from molecular dynamics simulations;Nature Protocols;2022-03-11

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