Design of Benzamidine-Type Inhibitors of Factor Xa-Reference-Cited by-同舟云学术

Design of Benzamidine-Type Inhibitors of Factor Xa

Published:1998-09-24 Issue:22 Volume:41 Page:4240-4250
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gabriel Bernhard¹,Stubbs Milton T.¹,Bergner Andreas¹,Hauptmann Jörg¹,Bode Wolfram¹,Stürzebecher Jörg¹,Moroder Luis¹

Affiliation:

1. Max-Planck-Institut für Biochemie, Am Klopferspitz 18A, D-82152 Martinsried, Germany, Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, D-35032 Marburg, Germany, and Zentrum für Vaskuläre Biologie und Medizin, Friedrich-Schiller-Universität Jena, D-99089 Erfurt, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980227t

Reference45 articles.

1. The clot thickens: clues provided by thrombin structure

2. Structure of Human Des(1-45) Factor Xa at 2·2 Å Resolution

3. The refined 1.9 A crystal structure of human alpha-thrombin: interaction with D-Phe-Pro-Arg chloromethylketone and significance of the Tyr-Pro-Pro-Trp insertion segment.

4. The refined 1.9-Å X-ray crystal structure of d-Phe-Pro-Arg chloromethylketone-inhibited humanα-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships

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