A Strategy for assessing peak purity of pharmaceutical peptides in reversed-phase chromatography methods using two-dimensional liquid chromatography coupled to mass spectrometry. Part II: Development of second-dimension gradient conditions

Author:

Stoll Dwight R.ORCID,Sylvester MariaORCID,Euerby Melvin R.ORCID,Buckenmaier Stephan M.C.,Petersson Patrik

Funder

Agilent Technologies

Agilent Foundation

Publisher

Elsevier BV

Subject

Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry

Reference16 articles.

1. RTTNews.com, Top 10 blockbuster drugs in 2021, n.d. https://www.nasdaq.com/articles/top-10-blockbuster-drugs-in-2021 (accessed August 15, 2022).

2. Peptide and protein based pharmaceuticals;Mezo,2013

3. Chapter 9 - Applications of Two-Dimensional Liquid Chromatography for Analysis of Synthetic Pharmaceutical Materials;Goyon,2023

4. Multiple heart-cutting two dimensional liquid chromatography mass spectrometry: towards real time determination of related impurities of bio-pharmaceuticals in salt based separation methods;Petersson;J. Chromatogr. A,2016

5. A selective comprehensive reversed-phase×reversed-phase 2D-liquid chromatography approach with multiple complementary detectors as advanced generic method for the quality control of synthetic and therapeutic peptides;Karongo;J. Chromatogr. A.,2020

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