Multiple heart-cutting two dimensional liquid chromatography mass spectrometry: Towards real time determination of related impurities of bio-pharmaceuticals in salt based separation methods

Author:

Petersson Patrik,Haselmann Kim,Buckenmaier Stephan

Publisher

Elsevier BV

Subject

Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry

Reference28 articles.

1. Detection of impurities by heart cutting using the Agilent 1290 infinity 2D-LC solution;Naegele;Agilent Technol. Appl. Note,2012

2. Assessing stability-indicating methods for coelution by two-dimensional liquid chromatography with mass spectrometric detection;Venkatramani;J. Sep. Sci.,2014

3. Peak purity assessment in a triple-active fixed-dose combination drug product related substances method using a commercial two-dimensional liquid chromatography system;Shackman;J. Sep. Sci.,2014

4. Enhancing 2D-LC analysis using the multiple heat-cutting technology;Buckenmaier;Chromatogr. Today,2015

5. Comprehensive two-dimensional liquid chromatography separations of pharmaceutical samples using dual Fused-Core columns in the 2nd dimension;Alexander;J. Chromatogr. A,2009

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