Development of multiple heartcutting two-dimensional liquid chromatography with ion-pairing reversed-phase separations in both dimensions for analysis of impurities in therapeutic oligonucleotides

Author:

Stoll DwightORCID,Sylvester MariaORCID,Meston DanielORCID,Sorensen MattORCID,Maloney Todd D.ORCID

Funder

National Science Foundation

Agilent Technologies

Publisher

Elsevier BV

Subject

Organic Chemistry,General Medicine,Biochemistry,Analytical Chemistry

Reference32 articles.

1. Pharmaceutical Stress Testing: Predicting Drug Degradation, Second Edition;Baertschi,2016

2. Impurities in oligonucleotide drug substances and drug products;Capaldi;Nucleic Acid Ther.,2017

3. Analysis of oligonucleotides by liquid chromatography;Goyon,2023

4. Chromatographic approaches for the characterization and quality control of therapeutic oligonucleotide impurities;El Zahar;Biomed. Chromatogr.,2018

5. Advantages of ion-exchange chromatography for oligonucleotide analysis;Cook;Bioanalysis,2011

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