A sensitive mutation screening method supporting cell line development for biotherapeutics

Author:

Valisheva Ildana,Harris Reed J.,Zhu-Shimoni Judith

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology,Biochemistry,Biophysics

Reference11 articles.

1. Antibody production;Birch;Adv. Drug Deliv. Rev.,2006

2. Mechanisms of unintended amino acid sequence changes in recombinant monoclonal antibodies expressed in Chinese hamster ovary (CHO) cells;Guo;Biotechnol. Bioeng.,2010

3. Detecting low level sequence variants in recombinant monoclonal antibodies;Yang;MAbs,2010

4. Identification of a single base-pair mutation of TAA (stop codon)--> GAA (Glu) that causes light chain extension in a CHO cell derived IgG1;Zhang;MAbs,2012

5. Assessing genetic heterogeneity in production cell lines: detection by peptide mapping of a low level Tyr to Gln sequence variant in a recombinant antibody;Harris;Biotechnol. (N. Y.),1993

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