Identification of a single base-pair mutation of TAA (Stop codon) → GAA (Glu) that causes light chain extension in a CHO cell derived IgG1-Reference-Cited by-同舟云学术

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Identification of a single base-pair mutation of TAA (Stop codon) → GAA (Glu) that causes light chain extension in a CHO cell derived IgG1

Published:2012-11 Issue:6 Volume:4 Page:694-700
ISSN:1942-0862
Container-title:mAbs
language:en
Short-container-title:mAbs

Author:

Zhang Taylor,Huang Yungfu,Chamberlain Scott,Romeo Tony,Zhu-Shimoni Judith,Hewitt Daniel,Zhu Mary,Katta Viswanatham,Mauger Brad,Kao Yung-Hsiang

Publisher

Informa UK Limited

Subject

Immunology,Immunology and Allergy

Link

http://www.tandfonline.com/doi/pdf/10.4161/mabs.22232

Reference29 articles.

1. Detecting low level sequence variants in recombinant monoclonal antibodies

2. Identification of Codon-Specific Serine to Asparagine Mistranslation in Recombinant Monoclonal Antibodies by High-Resolution Mass Spectrometry

3. Detection and identification of a serine to arginine sequence variant in a therapeutic monoclonal antibody

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