Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity-Reference-Cited by-同舟云学术

Optimization of the β-Aminoester class of factor Xa inhibitors. part 2: Identification of FXV673 as a potent and selective inhibitor with excellent In vivo anticoagulant activity

Published:2002-06 Issue:12 Volume:12 Page:1671-1674
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Guertin Kevin R,Gardner Charles J,Klein Scott I,Zulli Allison L,Czekaj Mark,Gong Yong,Spada Alfred P,Cheney Daniel L,Maignan Sebastian,Guilloteau Jean-Pierre,Brown Karen D,Colussi Dennis J,Chu Valeria,Heran Christopher L,Morgan Suzanne R,Bentley Ross G,Dunwiddie Christopher T,Leadley Robert J,Pauls Henry W

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference21 articles.

1. The coagulation cascade: initiation, maintenance, and regulation

2. Factor Xa Inhibitors as Novel Antithrombotic Agents: Facts and Perspectives

3. Identification and Initial Structure−Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa

4. Optimization of the β-Aminoester class of factor Xa inhibitors. part 1: P4 and side-Chain modifications for improved In vitro potency

5. New Data on the Pharmacology of Heparin and Low Molecular Weight Heparins

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