1. Departments of Cardiovascular Drug Discovery and New Leads Generation, Rhône-Poulenc Rorer, 500 Arcola Road, Collegeville, Pennsylvania 19426, Department of Metabolic Diseases, Hoffman La-Roche, 340 Kingsland Street, Nutley, New Jersey 07110, and Bristol Myers-Squibb, Route 206 and Province Line Road, Lawrenceville, New Jersey 08648