Optimization of the β-Aminoester class of factor Xa inhibitors. part 1: P4 and side-Chain modifications for improved In vitro potency-Reference-Cited by-同舟云学术

Optimization of the β-Aminoester class of factor Xa inhibitors. part 1: P4 and side-Chain modifications for improved In vitro potency

Published:2002-06 Issue:12 Volume:12 Page:1667-1670
ISSN:0960-894X
Container-title:Bioorganic & Medicinal Chemistry Letters
language:en
Short-container-title:Bioorganic & Medicinal Chemistry Letters

Author:

Czekaj Mark,Klein Scott I,Guertin Kevin R,Gardner Charles J,Zulli Allison L,Pauls Henry W,Spada Alfred P,Cheney Daniel L,Brown Karen D,Colussi Dennis J,Chu Valeria,Leadley Robert J,Dunwiddie Christopher T

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Drug Discovery,Pharmaceutical Science,Molecular Biology,Molecular Medicine,Biochemistry

Reference13 articles.

1. Factor Xa Inhibitors as Novel Antithrombotic Agents: Facts and Perspectives

2. The coagulation cascade: initiation, maintenance, and regulation

3. The Design of Competitive, Small-molecule Inhibitors of Coagulation Factor Xa

4. Progress in the design of inhibitors of coagulation factor Xa

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