Could PROTACs Protect Us From COVID-19?
Author:
Funder
U.S. National Institutes of Health
Publisher
Elsevier BV
Subject
Drug Discovery,Pharmacology
Reference11 articles.
1. Induced protein degradation: an emerging drug discovery paradigm;Lai;Nat. Rev. Drug Discov.,2017
2. Proteolysis Targeting chimeras for the selective degradation of Mcl-1/Bcl-2 derived from nonselective target binding ligands;Wang;J. Med. Chem.,2019
3. Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead;Bondeson;Cell Chem. Biol.,2018
4. Specific MHC-I Peptides Are Induced Using PROTACs;Jensen;Front Immunol.,2018
5. Structural basis of PROTAC cooperative recognition for selective protein degradation;Gadd;Nat. Chem. Biol.,2017
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1. Design, synthesis, and biological evaluation of first-in-class indomethacin-based PROTACs degrading SARS-CoV-2 main protease and with broad-spectrum antiviral activity;European Journal of Medicinal Chemistry;2024-02
2. Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2;ACS Medicinal Chemistry Letters;2024-01-10
3. Targeted degrader technologies as prospective SARS-CoV-2 therapies;Drug Discovery Today;2024-01
4. Intracellular Degradation of SARS-CoV-2 N-Protein Caused by Modular Nanotransporters Containing Anti-N-Protein Monobody and a Sequence That Recruits the Keap1 E3 Ligase;Pharmaceutics;2023-12-19
5. Discovery of First-in-Class PROTAC Degraders of SARS-CoV-2 Main Protease;2023-09-29
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