Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2-Reference-Cited by-同舟云学术

Development of a GC-376 Based Peptidomimetic PROTAC as a Degrader of 3-Chymotrypsin-like Protease of SARS-CoV-2

Published:2024-01-10 Issue:2 Volume:15 Page:250-257
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Grifagni Deborah¹²,Lenci Elena²^ORCID,De Santis Alessia¹²,Orsetti Andrea¹²,Barracchia Carlo Giorgio³^ORCID,Tedesco Filomena²,Bellini Puglielli Raffaele²,Lucarelli Francesca¹²,Lauriola Angela³,Assfalg Michael³^ORCID,Cantini Francesca¹²,Calderone Vito¹²^ORCID,Guardavaccaro Daniele³,Trabocchi Andrea²^ORCID,D’Onofrio Mariapina³^ORCID,Ciofi-Baffoni Simone¹²⁴^ORCID

Affiliation:

1. Magnetic Resonance Center CERM, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Florence, Italy

2. Department of Chemistry “Ugo Schiff”, University of Florence, Via della Lastruccia 3-13, 50019 Sesto Fiorentino, Florence, Italy

3. Department of Biotechnology, University of Verona, Strada le Grazie 15, 37134 Verona, Italy

4. Consorzio Interuniversitario Risonanze Magnetiche di Metalloproteine (CIRMMP), Via L. Sacconi 6, 50019 Sesto Fiorentino, Italy

Funder

European Commission

Ministero dell'Universit? e della Ricerca

Fondo di beneficienza ed opere di carattere sociale e culturale of Intesa Sanpaolo

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00498

Reference56 articles.

1. PROTACs: past, present and future

2. Driving E3 Ligase Substrate Specificity for Targeted Protein Degradation: Lessons from Nature and the Laboratory

3. Small-Molecule PROTACS: New Approaches to Protein Degradation

4. Transforming targeted cancer therapy with PROTACs: A forward-looking perspective

5. Targeted protein degraders crowd into the clinic

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