Binding thermodynamics discriminates fragments from druglike compounds: a thermodynamic description of fragment-based drug discovery
Author:
Funder
National Brain Research Program
Publisher
Elsevier BV
Subject
Drug Discovery,Pharmacology
Reference28 articles.
1. Enthalpic efficiency of ligand binding;Ferenczy;J. Chem. Inf. Model.,2010
2. Adding calorimetric data to decision making in lead discovery: a hot tip;Ladbury;Nat. Rev. Drug Discov.,2010
3. Thermodynamics of fragment binding;Ferenczy;J. Chem. Inf. Model.,2012
4. Applying thermodynamic profiling in lead finding and optimisation;Klebe;Nat. Rev. Drug Discov.,2015
5. Molecular complexity and its impact on the probability of finding leads for drug discovery;Hann;J. Chem. Inf. Comput. Sci.,2001
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