A semi-automated method for measuring the potential for protein covalent binding in drug discovery

Author:

Day S.H.,Mao A.,White R.,Schulz-Utermoehl T.,Miller R.,Beconi M.G.

Publisher

Elsevier BV

Subject

Pharmacology,Toxicology

Reference17 articles.

1. Diclofenac-associated hepatotoxicity: Analysis of 180 cases reported to the food and drug administration as adverse reactions;Banks;Hepatology,1995

2. Microsomal metabolism of the 5-lipoxygenase inhibitors L-746530 and L-739010 to reactive intermediates that covalently bind to protein: The role of the 6,8-dioxobicyclo[3.2.1]octanyl moiety;Chauret;Drug Metabolism and Disposition,1995

3. Semi-automated assay for covalent protein binding of drug candidates;Day;ISSX Proceedings,1999

4. Drug–protein adducts: An industry perspective on minimizing the potential for drug bioactivation in drug discovery and development;Evans;Chemical Research in Toxicology,2004

5. Reappraisal of human CYP isoforms involved in imipramine N-demethylation and 2-hydroxylation: A study using microsomes from putative extensive and poor metabolizers of S-mephenytoin and eleven recombinant human CYPs;Koyama;Journal of Pharmacology and Experimental Therapeutics,1997

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